Research

Dietary restriction and the aging brain

Understanding aging and its associated challenges, particularly in the context of an aging population, is of paramount importance. Age-related diseases, such as neurodegenerative disorders, pose significant burdens on society. However, studies focused on investigating these diseases have provided valuable insights into the process of aging itself. Among the various interventions studied, dietary restriction (DR) has emerged as a highly effective means of extending healthy lifespan across different species, ranging from yeast to flies to mammals. While our understanding of the mechanisms through which DR affects brain function is still developing, recent research has shed light on its potential benefits. Epidemiological studies have demonstrated that DR can reduce the risk of both Parkinson's and Alzheimer's disease. In animal models, DR has shown promise in ameliorating cognitive decline associated with Alzheimer's disease and improving motor and memory dysfunctions induced by toxins. These findings highlight the potential of targeting DR-related molecules and pathways for the treatment of age-related diseases. In our laboratory, we are dedicated to conducting a systematic investigation into the effects of DR on the aging brain. By unraveling the molecular underpinnings of how DR influences cognition, we aim to develop strategies that protect neurons from insults and enhance mental fitness. This research holds the potential to unlock novel therapeutic approaches for promoting healthy brain aging and combating age-related cognitive decline.

Development of anti-aging interventions

We conducted high-throughput gene expression profiling to investigate the mechanisms underlying the lifespan-extending effects of DR. Through this approach, we discovered several novel longevity genes that show potential as targets for the development of DR mimetics. By targeting these genes, we aim to replicate the beneficial effects of DR without the need for strict dietary interventions, offering alternative approaches to promote healthy aging. In addition to the genetic aspect, we also conducted screenings of natural products, specifically Chinese herbs, to identify compounds that possess anti-aging properties. This screening process allowed us to identify natural compounds with the potential to counteract the aging process and potentially treat age-related diseases. Our goal is to develop interventions that not only extend lifespan but also improve overall health and well-being during the aging process.

飲食限制與老化的大腦

由於人口結構老化以及高齡社會所造成的負擔，老化的議題儼然成為人類現今生活上所面臨的一大挑戰。近來許多著重於老化及疾病的相關研究讓我們對於衰老現象有著些許的了解，而其中飲食限制已經在各種生物實驗結果中證實具有有效延長壽命的效果。雖然對飲食限制與大腦相關的研究才剛起步，在臨床研究以及動物實驗上已發現可降低巴金森氏症及阿茲海默症的發生，且可有效減緩神經毒素所造成的傷害，這些結果顯示出飲食限制對於生物個體及細胞所引起的分子機制是未來抗老化研究的重要標的。本實驗室對飲食限制於大腦老化過程中的影響將作系統性的分析，而瞭解飲食限制調控認知功能的分子機轉將有利於保護神經損傷並維持心智健康。

抗衰老藥物之研究開發

利用高速基因表現分析法，我們對於飲食限制延緩老化的分子機轉已有初步的研究，也因此發現許多新的長壽基因，而這些基因極具研究潛力，並可能成為飲食限制擬藥的研發標的。此外，我們利用帶有類似巴金森氏症、阿茲海默症及亨丁頓舞蹈症的模式生物進行試驗，藉此篩選具有抗衰老功效的天然物或中草藥，而這些藥物的開發將有助於人類活的健康長壽。