Publications

研究論文

  • Chiang CH, Li SJ, Lin YH, Wang PY, Hsu PS, Lin SP, Chiang TC, Chen CY (2023) Early‐onset caloric restriction alleviates ageing‐associated steatohepatitis in male mice via restoring mitochondrial homeostasis. Biogerontology 24, 391–401.
  • Lin WS, Wang PY (2022) Janus-faced citrate in aging and metabolism. Aging (Albany NY). 14
  • Lin WS, Lin SJ, Liao PY, Suresh D, Hsu TR, Wang PY (2022) The role of ketogenic diet in multiple sclerosis and related animal models: an updated review. Advances in Nutrition. nmac065.
  • Chen HH, Lu HY, Chang CH, Lin SH, Huang CW, Wei PH, Chen YW, Lin YR, Huang HS, Wang PY, Tsao YP, Chen SL (2022) Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin. Stem Cell Research & Therapy. 13, 160.
  • Li SJ, Lin YH, Chiang CH, Wang PY, Chen CY (2022) Early-onset dietary restriction maintains mitochondrial health, autophagy and ER function in the left ventricle during aging. Journal of Nutritional Biochemistry. 101:108944.
  • Fan SZ, Lin CS, Wei YW, Yeh SR, Tsai YH, Lee AC, Lin WS, Wang PY (2021) Dietary citrate supplementation enhances longevity, metabolic health and memory performance through promoting ketogenesis. Aging Cell. 20(12):e13510.
  • Fan SZ, Sung CW, Tsai YH, Yeh SR, Lin WS, Wang PY (2020) Nervous system deletion of mammalian INDY in mice mimics dietary restriction-induced memory enhancement. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 76(1):50-56.
  • Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH (2020) Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 17(138).
  • Teng LL, Lu GL, Chiou LC, Lin WS, Cheng YY, Hsueh TE, Huang YC, Hwang NH, Yeh JW, Liao RM, Fan SZ, Yen JH, Fu TF, Tsai TF, Wu MS, Wang PY (2019) Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement. PLoS Biology. 17(3): e2007097.
  • Lin WS, Yeh SR, Fan SZ, ChenLY, Yen JH, Fu TF, Wu MS, Wang PY (2018) Insulin signaling in female Drosophila links diet and sexual attractiveness. FASEB J. 32:3870-3877.
  • Chen HH, Tsai LK, Liao KY, Wu TC, Huang YH, Huang YC, Chang SW, Wang PY, Tsao YP, Chen SL (2018) Muscle-restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down-regulation of myogenin at the neuromuscular junction. J Cachexia Sarcopenia Muscle. 9:771-785.
  • Kuo PC, Brown DA, Scofield BA, Paraiso HC, Wang PY, Yu IC, Yen JH (2018) Dithiolethione ACDT suppresses neuroinflammation and ameliorates disease severity in experimental autoimmune encephalomyelitis. Brain, Behavior, and Immunity. 70:76-87.
  • Lin WS, Lo JH, Yang JH, Wang HW, Fan SZ, Yen JH, Wang PY (2017) Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice. Journal of Ethnopharmacology. 207:211-219.
  • Chen SL, Chen YH, Wang CC, Yu YW, Tsai YC, Hsu HW, Wu CL, Wang PY, Chen LC, Lan TH, Fu TF (2017) Active and passive sexual roles that arise in Drosophila male-male courtship are modulated by dopamine levels in PPL2ab neurons. Scientific Reports. 7:44595.
  • Huang CW, Chen YW, Lin YR, Chen PH, Chou MH, Lee LJ, Wang PY, Wu JT, Tsao YP, Chen SL (2016) Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin. Scientific Reports. 6:34927.
  • Kuo PC, Brown DA, Scofield BA, IC Yu, Chang FL, Wang PY, Yen JH (2016) 3H-1, 2-Dithiole-3-Thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis. Brain, Behavior, and Immunity. 57:173-186
  • Klionsky DJ et al., (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222.
  • Lin WS, Huang CW, Song YS, Yen JH, Kuo PC, Yeh SR, Lin HY, Fu TF, Wu MS, Wang HD, Wang PY (2015) Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice. PLoS ONE10(10): e0139722.
  • Huang CW, Wang HD, Bai H, Wu MS, Yen JH,Tatar M, Fu TF and Wang PY (2015) Tequila regulates insulin-like signaling and extends life span in Drosophila melanogaster. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 70 (12): 1461-1469.
  • Kuo SY, Wu CL, Hsieh MY, Lin CT, Wen RK, Chen LC, Chen YH, Yu YW, Wang HD, Su YJ, Lin CJ, Yang CY, Guan HY, Wang PY, Lan TH, and Fu TF (2015) PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine. Nature Communications. 6:7490.
  • Lin WS, Chen JY, Wang JC, Chen LY, Lin CH, Hsieh TR, Wang MF and Fu TF, Wang PY (2014) The Anti-aging Effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 Mice. AGE. 36 (2): 689-703.
  • Chou HJ, Lai DM, Huang CW, McLennan IS, Wang HD, Wang PY (2013) BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced exictotoxicity in vitro. PLoS ONE. 8 (3): e58441.
  • Chen SF, Kang ML, Chen YC, Tang HW, Huang CW, Li WH, Lin CP, Wang CY, Wang PY, Chen GC, et al (2012) Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. Journal of Biomedical Science. 19, 52.
  • Clarkson AN, Talbot CL, Wang PY, MacLaughlin DT, Donahoe PK, and McLennan IS (2011) Mullerian inhibiting substance is anterogradely transported and does not attenuate avulsion-induced death of hypoglossal motor neurons. Experimental Neurology. 231, 304-308.
  • Azhar M, Wang PY, Frugier T, Koishi K, Deng C, Noakes PG and McLennan IS (2010) Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. International Journal of Biological Sciences. 6, 546-555.
  • Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL (2009) Long-lived Indy and calorie restriction interact to extend life span. Proc. Natl. Acad. Sci. USA. 106:9262-9267.
  • Wang PY, Protheroe A, Clarkson AN, Imhoff F, Koishi K and McLennan, IS (2009) Müllerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior. Proc. Natl. Acad. Sci. USA. 106:7203-7208.
  • Neretti N*, Wang PY*, Brodsky AS, Nyguyen H, White KP, Rogina B and Helfand SL (2009) Long-lived Indy induces reduced mitochondrial ROS production and oxidative damage. Proc. Natl. Acad. Sci. USA. 106:2277-2282. *Co-first author.
  • Wang PY, Koishi K and McLennan IS (2007) BMP6 is axonally transported by motoneurons and supports their survival in vitro. Molecular and Cellular Neuroscience. 34: 653-661.
  • Wang PY, Koishi K, McGeachie AB, Kimber M, MacLaughlin DT, Donahoe PK and McLennan IS (2005) Mullerian inhibiting substance acts as a motor neuron survival factor in vitro. Proc. Natl. Acad. Sci. USA. 102:16421-16425.